Pulmonary alveolar microlithiasis (PAM) is one of the rare lung diseases, in which an otherwise healthy individual develops diffuse alveolar calcifications. It is reported to be caused by mutation of the SLC34A2 gene. Patients who are eventually diagnosed with PAM usually present late when progression to cor pulmonale has already developed, or for other reasons not related to the disease itself when their clinical work up results incidentally reveal much worse findings than the patient’s actual state. Unlike the familiar information that no effective treatment other than lung transplant, cardiokinetics, diuretics, oxygen, and repeated bronchoalveolar lavage were reported with relatively satisfactory results and chest X-ray changes. In this report, we focus on the relation between clinical, radiologic and histologic findings, in which clinical scenario was first mistaken for interstitial fibrosis or suspected metastasis, and on literature review. Chest radiography, bronchoalveolar lavage and lung wedge biopsy were the main steps to reach the diagnosis of PAM. Gradual improvement after conservative treatment was noted prior to discharge. Then clinic appointment for follow up and family members surveillance was scheduled. A rare disease incidentally diagnosed by high awareness of the attending physician and simple methods that points to a question of disease prevalence in Jordan.
| Published in | Science Journal of Clinical Medicine (Volume 13, Issue 4) |
| DOI | 10.11648/j.sjcm.20241304.13 |
| Page(s) | 76-80 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Lung Calcification, Pulmonary Alveolar Microlithiasis, Stone Lung
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APA Style
Alakhras, B. R., Habashneh, O., Yaghi, A. B., Daseh, A., Alkilani, A. (2024). Pulmonary Alveolar Microlithiasis: An Incidental Case Report from Jordan with Literature Review. Science Journal of Clinical Medicine, 13(4), 76-80. https://doi.org/10.11648/j.sjcm.20241304.13
ACS Style
Alakhras, B. R.; Habashneh, O.; Yaghi, A. B.; Daseh, A.; Alkilani, A. Pulmonary Alveolar Microlithiasis: An Incidental Case Report from Jordan with Literature Review. Sci. J. Clin. Med. 2024, 13(4), 76-80. doi: 10.11648/j.sjcm.20241304.13
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Download@article{10.11648/j.sjcm.20241304.13,
author = {Basheer Radi Alakhras and Omar Habashneh and Ahmad Basim Yaghi and Abdallah Daseh and Adham Alkilani},
title = {Pulmonary Alveolar Microlithiasis: An Incidental Case Report from Jordan with Literature Review
},
journal = {Science Journal of Clinical Medicine},
volume = {13},
number = {4},
pages = {76-80},
doi = {10.11648/j.sjcm.20241304.13},
url = {https://doi.org/10.11648/j.sjcm.20241304.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20241304.13},
abstract = {Pulmonary alveolar microlithiasis (PAM) is one of the rare lung diseases, in which an otherwise healthy individual develops diffuse alveolar calcifications. It is reported to be caused by mutation of the SLC34A2 gene. Patients who are eventually diagnosed with PAM usually present late when progression to cor pulmonale has already developed, or for other reasons not related to the disease itself when their clinical work up results incidentally reveal much worse findings than the patient’s actual state. Unlike the familiar information that no effective treatment other than lung transplant, cardiokinetics, diuretics, oxygen, and repeated bronchoalveolar lavage were reported with relatively satisfactory results and chest X-ray changes. In this report, we focus on the relation between clinical, radiologic and histologic findings, in which clinical scenario was first mistaken for interstitial fibrosis or suspected metastasis, and on literature review. Chest radiography, bronchoalveolar lavage and lung wedge biopsy were the main steps to reach the diagnosis of PAM. Gradual improvement after conservative treatment was noted prior to discharge. Then clinic appointment for follow up and family members surveillance was scheduled. A rare disease incidentally diagnosed by high awareness of the attending physician and simple methods that points to a question of disease prevalence in Jordan.
},
year = {2024}
}
TY - JOUR T1 - Pulmonary Alveolar Microlithiasis: An Incidental Case Report from Jordan with Literature Review AU - Basheer Radi Alakhras AU - Omar Habashneh AU - Ahmad Basim Yaghi AU - Abdallah Daseh AU - Adham Alkilani Y1 - 2024/12/16 PY - 2024 N1 - https://doi.org/10.11648/j.sjcm.20241304.13 DO - 10.11648/j.sjcm.20241304.13 T2 - Science Journal of Clinical Medicine JF - Science Journal of Clinical Medicine JO - Science Journal of Clinical Medicine SP - 76 EP - 80 PB - Science Publishing Group SN - 2327-2732 UR - https://doi.org/10.11648/j.sjcm.20241304.13 AB - Pulmonary alveolar microlithiasis (PAM) is one of the rare lung diseases, in which an otherwise healthy individual develops diffuse alveolar calcifications. It is reported to be caused by mutation of the SLC34A2 gene. Patients who are eventually diagnosed with PAM usually present late when progression to cor pulmonale has already developed, or for other reasons not related to the disease itself when their clinical work up results incidentally reveal much worse findings than the patient’s actual state. Unlike the familiar information that no effective treatment other than lung transplant, cardiokinetics, diuretics, oxygen, and repeated bronchoalveolar lavage were reported with relatively satisfactory results and chest X-ray changes. In this report, we focus on the relation between clinical, radiologic and histologic findings, in which clinical scenario was first mistaken for interstitial fibrosis or suspected metastasis, and on literature review. Chest radiography, bronchoalveolar lavage and lung wedge biopsy were the main steps to reach the diagnosis of PAM. Gradual improvement after conservative treatment was noted prior to discharge. Then clinic appointment for follow up and family members surveillance was scheduled. A rare disease incidentally diagnosed by high awareness of the attending physician and simple methods that points to a question of disease prevalence in Jordan. VL - 13 IS - 4 ER -
Pathology Department, Albasheer Hospital, Amman, Jordan
Pathology Department, Albasheer Hospital, Amman, Jordan
Radiology Department, Albasheer Hospital, Amman, Jordan
Faculty of Medicine, Hashemite University, Zarqa, Jordan
Department of General Surgery, Albasheer Hospital, Amman, Jordan
