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Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023

Received: 15 June 2024     Accepted: 4 July 2024     Published: 15 August 2024
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Abstract

Background: Tuberculosis (TB) remains a significant public health concern globally, especially among HIV-positive individuals. The study aimed to investigate the factors associated with mortality among HIV/TB co-infected patients receiving antiretroviral therapy (ART) in Dire Dawa, Ethiopia. Methods: A retrospective follow-up study was conducted at Dilchora Referral Hospital among 434 HIV/TB co-infected patients enrolled in ART from January 2008 to January 2023. Standardized checklist was used for data collection and taken from patient’s medical cards and database system. Binary logistic regression was used to identify baseline factors associated with mortality. Results: The study found a mortality rate of 31% among HIV/TB co-infected patients. Factors such as WHO clinical stage III (AOR: 9.3, 95% CI: 3.03, 28.34) and WHO clinical stage IV (AOR: 11.3, 95% CI: 3.5, 36.34) and underweight and overweight body mass index were (AOR: 2.6, 95% CI: 1.35, 4.83) and (AOR: 21.4, 95% CI: 8.24, 55.5), poor ART adherence (AOR: 4.24, 95% CI: 2.25, 7.98), alcohol consumption (AOR: 3.15, 95%: 1.69, 5.87), and smoking (AOR: 4.12, 95% CI: 2.32, 7.29) were associated with increased odds of mortality. Conclusion: The study underscores the importance of identifying and addressing baseline factors that contribute to mortality in HIV/TB co-infected patients. Interventions targeting factors like clinical staging, adherence to ART, and lifestyle habits could help reduce mortality rates in this population.

Published in Science Journal of Clinical Medicine (Volume 13, Issue 3)
DOI 10.11648/j.sjcm.20241303.11
Page(s) 38-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Mortality, HIV/TB Co-infection, Antiretroviral Therapy, Ethiopia

References
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  • APA Style

    Bayisa, F. S., Nimani, T. D. (2024). Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023. Science Journal of Clinical Medicine, 13(3), 38-46. https://doi.org/10.11648/j.sjcm.20241303.11

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    ACS Style

    Bayisa, F. S.; Nimani, T. D. Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023. Sci. J. Clin. Med. 2024, 13(3), 38-46. doi: 10.11648/j.sjcm.20241303.11

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    AMA Style

    Bayisa FS, Nimani TD. Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023. Sci J Clin Med. 2024;13(3):38-46. doi: 10.11648/j.sjcm.20241303.11

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  • @article{10.11648/j.sjcm.20241303.11,
      author = {Feyisa Shasho Bayisa and Teshome Demis Nimani},
      title = {Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023
    },
      journal = {Science Journal of Clinical Medicine},
      volume = {13},
      number = {3},
      pages = {38-46},
      doi = {10.11648/j.sjcm.20241303.11},
      url = {https://doi.org/10.11648/j.sjcm.20241303.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20241303.11},
      abstract = {Background: Tuberculosis (TB) remains a significant public health concern globally, especially among HIV-positive individuals. The study aimed to investigate the factors associated with mortality among HIV/TB co-infected patients receiving antiretroviral therapy (ART) in Dire Dawa, Ethiopia. Methods: A retrospective follow-up study was conducted at Dilchora Referral Hospital among 434 HIV/TB co-infected patients enrolled in ART from January 2008 to January 2023. Standardized checklist was used for data collection and taken from patient’s medical cards and database system. Binary logistic regression was used to identify baseline factors associated with mortality. Results: The study found a mortality rate of 31% among HIV/TB co-infected patients. Factors such as WHO clinical stage III (AOR: 9.3, 95% CI: 3.03, 28.34) and WHO clinical stage IV (AOR: 11.3, 95% CI: 3.5, 36.34) and underweight and overweight body mass index were (AOR: 2.6, 95% CI: 1.35, 4.83) and (AOR: 21.4, 95% CI: 8.24, 55.5), poor ART adherence (AOR: 4.24, 95% CI: 2.25, 7.98), alcohol consumption (AOR: 3.15, 95%: 1.69, 5.87), and smoking (AOR: 4.12, 95% CI: 2.32, 7.29) were associated with increased odds of mortality. Conclusion: The study underscores the importance of identifying and addressing baseline factors that contribute to mortality in HIV/TB co-infected patients. Interventions targeting factors like clinical staging, adherence to ART, and lifestyle habits could help reduce mortality rates in this population.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Mortality and Associated Factors Among HIV/TB Co-infected Patients Under ART Clinic in Dire Dawa, Ethiopia, 2023
    
    AU  - Feyisa Shasho Bayisa
    AU  - Teshome Demis Nimani
    Y1  - 2024/08/15
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    N1  - https://doi.org/10.11648/j.sjcm.20241303.11
    DO  - 10.11648/j.sjcm.20241303.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.sjcm.20241303.11
    AB  - Background: Tuberculosis (TB) remains a significant public health concern globally, especially among HIV-positive individuals. The study aimed to investigate the factors associated with mortality among HIV/TB co-infected patients receiving antiretroviral therapy (ART) in Dire Dawa, Ethiopia. Methods: A retrospective follow-up study was conducted at Dilchora Referral Hospital among 434 HIV/TB co-infected patients enrolled in ART from January 2008 to January 2023. Standardized checklist was used for data collection and taken from patient’s medical cards and database system. Binary logistic regression was used to identify baseline factors associated with mortality. Results: The study found a mortality rate of 31% among HIV/TB co-infected patients. Factors such as WHO clinical stage III (AOR: 9.3, 95% CI: 3.03, 28.34) and WHO clinical stage IV (AOR: 11.3, 95% CI: 3.5, 36.34) and underweight and overweight body mass index were (AOR: 2.6, 95% CI: 1.35, 4.83) and (AOR: 21.4, 95% CI: 8.24, 55.5), poor ART adherence (AOR: 4.24, 95% CI: 2.25, 7.98), alcohol consumption (AOR: 3.15, 95%: 1.69, 5.87), and smoking (AOR: 4.12, 95% CI: 2.32, 7.29) were associated with increased odds of mortality. Conclusion: The study underscores the importance of identifying and addressing baseline factors that contribute to mortality in HIV/TB co-infected patients. Interventions targeting factors like clinical staging, adherence to ART, and lifestyle habits could help reduce mortality rates in this population.
    
    VL  - 13
    IS  - 3
    ER  - 

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