Volume 9, Issue 3, September 2020, Page: 81-88
Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria
Collins Amadi, Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria
Olufisayo Gabriel Ayoade, Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria
Fabian Aniekpon Unyime, Department of Chemical Pathology, University of Uyo, Uyo, Nigeria
Sarah Ifreke Essien, Department of Chemical Pathology, University of Uyo, Uyo, Nigeria
Blessing Thomas Moses, Department of Biochemistry, Evangel University, Abakaliki, Nigeria
Mfonobong Eni Enyong, Department of Health Information Management, University of Uyo Teaching Hospital, Uyo, Nigeria
Received: Aug. 25, 2020;       Accepted: Sep. 10, 2020;       Published: Sep. 24, 2020
DOI: 10.11648/j.sjcm.20200903.16      View  209      Downloads  53
Abstract
Background: Dyslipidemia abounds among diabetics. However, these are poorly characterized among patients with type 1 diabetes (T1DM). The current study determined the pattern of dyslipidemia and their relationship with glycemic status among adult T1DM subjects. Methods: This survey was conducted retrospectively among 346 newly-diagnosed/treatment-naïve T1DM adults attending outpatient units of a third-level hospital in Nigeria. Patients’ fasting plasma glucose and lipid parameters at the time of T1DM diagnosis were abstracted from their medical files. Lipid parameters included triglyceride (Tg), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Abstracted parameters were analyzed using descriptive and comparative statistics. Results: Of the 346 studied, 46.8% (n=162) were dyslipidemic (aged: 32.69±6.29) with female predominance (59.3%; p=0.018). Categorically, females predominated among isolated dyslipidemics while males predominated among the combined/mixed dyslipidemics. High plasma Tg concentration (n=142;87.7%) was the most common isolated dyslipidemia without male/female difference (p>0.05); seconded by low HDL-C (n=80;49.4%) with the females predominating (p<0.05). The most combined and mixed dyslipidemia was high plasma Tg/low HDL-C (total n=28, 17.3%; males n=16, 24.2% vs. females n=12, 12.5%; p=0.011) and high plasma Tg/high LDL-C/low-HDL-C (total n=30, 18.5%; males n=18, 27.3% vs. females n=12, 12.5%; p=0.001) concentrations, respectively with male predominance. The female dyslipidemics were younger with lower BMI, higher systolic blood pressure, glycemia, and mean plasma Tg levels (p<0.05). The overall dyslipidemics had poor glycemic status and their risk of dyslipidemia increases with worsening glycemia. Conclusion: Dyslipidemia was common and associated with poor glycemic status among the studied cohorts. This finding informs the need for more rigorous monitoring of dyslipidemia among T1DM subjects to reduce the risk of its complications.
Keywords
Diabetes, Type 1 Diabetes, Lipid/Lipoprotein Abnormalities
To cite this article
Collins Amadi, Olufisayo Gabriel Ayoade, Fabian Aniekpon Unyime, Sarah Ifreke Essien, Blessing Thomas Moses, Mfonobong Eni Enyong, Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria, Science Journal of Clinical Medicine. Vol. 9, No. 3, 2020, pp. 81-88. doi: 10.11648/j.sjcm.20200903.16
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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