Volume 8, Issue 5, September 2019, Page: 49-53
The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma
Tinni Trihartini Maskoen, Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Budiana Rismawan, Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Rangga Saputra, Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Received: Jul. 22, 2019;       Accepted: Aug. 28, 2019;       Published: Sep. 17, 2019
DOI: 10.11648/j.sjcm.20190805.11      View  33      Downloads  16
Abstract
Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.
Keywords
Acute Kidney Injury, Multiple Trauma, Creatinine, Kidney Injury Molecule–1
To cite this article
Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra, The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma, Science Journal of Clinical Medicine. Vol. 8, No. 5, 2019, pp. 49-53. doi: 10.11648/j.sjcm.20190805.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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