Volume 8, Issue 1, January 2019, Page: 1-5
Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal
Maria Adelina Costa, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carlos Fardilha, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Graça Fonseca, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Joao Conde, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carmen Calcada, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Fatima Rodrigues, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Paula Genesio, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Fernanda Ponte, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Joana Vale, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Guilherme Campos, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carla Seixas, Medical Oncology Service, Hospital CUF, Porto, Portugal
Andre Ferreira, Medical Oncology Service, Hospital CUF, Porto, Portugal
Carla Sousa, Medical Oncology Service, Hospital CUF, Porto, Portugal
Moreira Pinto, Medical Oncology Service, Hospital CUF, Porto, Portugal
Paulo Costa, Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Received: Mar. 26, 2019;       Accepted: May 6, 2019;       Published: May 31, 2019
DOI: 10.11648/j.sjcm.20190801.11      View  22      Downloads  6
Abstract
Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.
Keywords
Radiotherapy, Hyperthermia, Locoregional Recurrence, Reirradiation
To cite this article
Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, Fatima Rodrigues, Paula Genesio, Fernanda Ponte, Joana Vale, Guilherme Campos, Carla Seixas, Andre Ferreira, Carla Sousa, Moreira Pinto, Paulo Costa, Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal, Science Journal of Clinical Medicine. Vol. 8, No. 1, 2019, pp. 1-5. doi: 10.11648/j.sjcm.20190801.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
J Zee, B Holt, PJM Rietveld, et al. Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. British Journal of cancer (1999) 79 (3/4), 483-490.
[2]
NG Huilgol, S Gupta, CR Sridhar. Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial. J. Cancer Res. Ther. (2010) 6 (4), 492-496.
[3]
M Mallory, E Gogineni, GC Jones, et al. Therapeutic hyperthermia: The old, the new, and the upcoming. Criticals Reviews in Oncology/Hematology 97 (2016), 56-64.
[4]
CA Perez, B Gillespie, T Pajak, et al. Quality assurance problems in clinical hyperthermia and their impact on therapeutic outcome: a Report by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys (1989) 16(3), 551-8.
[5]
International Collaborative Hyperthermia Group. Hyperthermia in the treatment of superficial localized primary and recurrent breast cancer – results from five randomized controlled trials. Int J Radiat Oncol Biol Phys (1996) 35, 731-744.
[6]
H Sahinbas. Retrospective clinical study for advanced brain gliomas by adjuvant electro-hyperthermia treatment. Cancer Therapy (2012) 8, 139-149.
[7]
HP Kok, J Crezee. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int J hyperthermia (2017) 33(4), 378-386.
[8]
NR Datta, S Rogers, SG Ordóñez, et al. Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis. Int J Hyperthermia (2016) 32(1), 31-40.
[9]
NR Datta, E Puric, D Klingbiel, et al. Hyperthermia and radiotherapy in locoregional recurrent breast cancers: A systematic review and meta-analysis. Int J Radiat Oncol Biol Phys (2016) 94(5), 1073-87.
[10]
NR Datta, SG Ordóñez, US Gaipl, et al. Local hyperthermia combined with radiotherapy and/or chemotherapy: recent advances and promises for the future. Cancer Treat Rev (2015) 41(9), 742-53.
[11]
NR Datta, E Puric, D Klingbiel, et al. Hyperthermia and radiation therapy in locoregional recurrent breast cancers: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys (2016) 94(5):1073–87.
[12]
NR Datta, S Rogers, D Klingbiel, et al. Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: a systematic review with conventional and network meta-analyses. Int J Hyperthermia (2016) 6736:1–34.
[13]
LCHW Lutgens, PCM Koper, JJ Jobsen, et al. Radiation therapy combined with hyperthermia versus cisplatin for locally advanced cervical cancer: results of the randomized RADCHOC trial. Radiother Oncol (2016) 120(3):378–82.
[14]
NR Datta, S Rogers, SG Ordonez, et al S. Hyperthermia and radiotherapy in the management of head and neck cancers: a systematic review and meta-analysis. Int J Hyperthermia (2016) 32(1):31–40.
[15]
C Zhao, J Chen, B Yu, et al. Improvement in quality of life in patients with nasopharyngeal carcinoma treated with non-invasive extracorporeal radiofrequency in combination with chemoradiotherapy. Int J Radiat Biol (2014) 90(10):853–8.
[16]
M Kang, WQ Liu, YT Qin, et al. Long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treatment of nasopharyngeal carcinoma with cervical lymph node metastases. Asian Pac J Cancer Prev (2013) 14(12):7395–400.
[17]
Linthorst M, Baaijens M, Wiggenraad R, et al. Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients. Radiotherapy and Oncology (2015) 117: 217-222.
[18]
Peeken JC, Vaupel P, Combs SE. Integrating hyperthermia into modern radiation oncology: what evidence is necessary? Frontiers in Oncology (2017) 7(132): 1-12.
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