Volume 7, Issue 2, March 2018, Page: 13-19
Current Review on Molecular and Phenotypic Mechanism of Bacterial Resistance to Antibiotic
Mesele Admassie, Department of Microbial, Cellular and Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia
Received: Mar. 9, 2018;       Accepted: Apr. 2, 2018;       Published: May 8, 2018
DOI: 10.11648/j.sjcm.20180702.11      View  760      Downloads  109
Abstract
Antibiotic-resistant bacteria that are difficult to treat are becoming increasingly common and are causing a global health crisis. molecular mechanism bacterial resistance of antibiotic is, necessary in order to find ways to avoid conditions that promote disobedient pathogens. The objectives of this seminar paper are to review the genetics of molecular mechanism of antibiotic resistance and to describe different molecular intrinsic, acquired, circumstantial resistance; genetics of antibiotic resistance and phenotypic drug resistance those specified by mechanisms confer antibiotic resistance. These drug resistance mechanisms allow bacteria that harbor these mechanisms to survive, or even to actively grow, in the presence of a given anti-microbial agent. Furthermore, certain bacterial variants have evolved mechanisms to resist multiple drugs, making such variants recalcitrant to chemotherapy against such bacterial strains that are the causative agents of infection in patients. Knowing the molecular mechanisms of antibiotic resistance is essential for developing new approaches to overcome and prevent drug resistance problems. Studding of development and mechanisms of resistance should be known at an early stage of drug development and strategies to improve the delivery or to enhancing the accessibility of antibiotics to their sites of action should be known.
Keywords
Antibiotic Resistant, Molecular Mechanism, Bacteria, Intrinsic Resistance
To cite this article
Mesele Admassie, Current Review on Molecular and Phenotypic Mechanism of Bacterial Resistance to Antibiotic, Science Journal of Clinical Medicine. Vol. 7, No. 2, 2018, pp. 13-19. doi: 10.11648/j.sjcm.20180702.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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