Volume 6, Issue 5, September 2017, Page: 82-85
Case Reports on Juvenile Xanthogranuloma and Brief Review of Literature
Sushmita Pradhan, Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China
Shuang Chen, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Lin Xiong, Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China
Received: Feb. 18, 2017;       Accepted: Mar. 18, 2017;       Published: Oct. 24, 2017
DOI: 10.11648/j.sjcm.20170605.14      View  1671      Downloads  62
Abstract
Juvenile xanthogranuloma is an unusual, self-limiting dermatological disorder occurring especially in infants, late childhood and rarely in adults. It belongs to the broad group of non-Langerhans cell histiocytosis. It usually appears as solitary or multiple papules, macules or nodules several millimeters in diameter with the head and neck being the most common site of involvement and vulva being the rare site. We report two cases of juvenile xanthogranuloma in an 18 months old female and 18 months old male. The female presented with three yellow papules measuring 2-3 mm in diameter around vulva region since 4 months. Similarly, the male presented with multiple tan-orange color macules on head and forehead measuring 3-4mm in diameter since 6 months. In both the cases, a biopsy without total excision was performed. The clinical and histopathological evaluation confirmed the diagnosis of juvenile xanthogranuloma. In childhood, juvenile xanthogranuloma is necessary to differentiate from another probable differential diagnosis by biopsy.
Keywords
Xanthogranuloma, Juvenile, Children
To cite this article
Sushmita Pradhan, Shuang Chen, Lin Xiong, Case Reports on Juvenile Xanthogranuloma and Brief Review of Literature, Science Journal of Clinical Medicine. Vol. 6, No. 5, 2017, pp. 82-85. doi: 10.11648/j.sjcm.20170605.14
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Dehner LP. Juvenile xanthogranuloma in the first decades of life. A clinicopathologic study of 174 cases with cutaneous an extracutaneous manifestations. Am J Surg Pathol. 2003; 5: 579-593.
[2]
George DH, Scheithauer BW, Hilton DL, Fakhouri AJ, Kraus EW. Juvenile xanthogranuloma of peripheral nerve: a report of two cases. Am J Surg Pathol. 2001; 25: 521-526.
[3]
Lesniak MS, Viglione MP, Weingart J. Multicentric parenchymal xanthogranuloma in a child: case report and review of the literature. Neurosurgery. 2002; 51: 1493-1498.
[4]
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB. Juvenile xanthogranuloma. J Am Acad Dermatol. 1997; 36: 335-367.
[5]
Cypel TKS, Zuker RM. Juvenile xanthogranuloma: case report and review of the literature. Can J Plast Surg. 2008; 16: 175-177.
[6]
Sangueza OP, Salmon JK, White CR Jr, Beckstead JH. Juvenile xanthogranuloma: a clinical histopathologic and immunohistochemical study. J Cutan Pathol. 1995; 22: 327-335.
[7]
Adamson HG. Society intelligence: The dermatologic society of London. Br J Dermatol. 1905; 17: 222.
[8]
Burgdorf WHC, Zelger B. Then on Langerhan’s cell histiocytosis in childhood. Cutis. 1996; 58: 201-207.
[9]
Kitchen ND, Davies MS, Taylor W. Juvenile xanthogranuloma of nerve root origin. Br J Neurosurg. 1995; 9: 233-237.
[10]
Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: A clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol. 2005; 29: 21-28.
[11]
Curtis T, Wheeler DT, Cibis GW, Law SK, Rowsey JJ, Brown LL, RoyH. Juvenilexanthogranuloma:[http://emedicine.medscape.com/article/1209681-overview]
[12]
Winkelmann RK. Cutaneous syndrome of non-X histiocytosis: A review of the macrophage histiocyte disease of the skin. Arch Dermatol. 1981; 117: 667-72.
[13]
Liu ZQ, Liu R, Shi XD, Li JX, Zou JZ. Juvenile xanthogranuloma: 3 cases report and literature review. Zhonghua XueYe Xue Za Zhi. 2011. Sep; 32 (9): 614-7.
[14]
Campoury M, Moreau-Cabarrot A, Gorguet B, Samalens G, Daste B, Eclache F, et al. Acquired regressive cutaneousnon-Langerhans’-cell histiocytosis in an infant. Ann Dermatol Venereol. 1997; 124: 167-70.
[15]
Gupta B, Yadav S, Khurana N, Sharma M. Juvenile xanthogranuloma in vulva of a 10-year-old child. Journal of Clinical and Diagnostic Research. 2016; 11: ED21-ED22.
[16]
Polat M, Topcuoglu MA, Tahtaci Y, Hapa A, Yilmaz F. Spitz nevus of the genital mucosa. Indian J Dermatol Venereol Leprol. 2009; 75: 167-69.
[17]
Rodriguez J, Ackerman B. Xanthogranuloma in adults. Arch Dermatol. 1976; 112: 43-44.
[18]
Castillo EA, Orms by-Adult xanthogranuloma of the vulva: case report and review. Pathology. 2002; 34: 86-87.
[19]
DeLuca IJ, Grossman ME. Vulvar necrobiotic xanthogranuloma. Journal of the American Academy of Dermatology. 2014; 71: e247-48.
[20]
Tran DT, Wolgamot GM, Olerud J, Hurst S, Argenyi Z. An ‘eruptive’ variant of juvenile xanthogranuloma associated with langerhans cell histiocytosis. Journal of Cutaneous Pathology. 2008; 35: 50-55.
[21]
Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol. 2005; 29: 21-28.
[22]
Santala M, Suonio S, Syrjanen K, Uronen MT, Saarikoski S. Malignant fibrous histiocytoma of the vulva. Gynecologic Oncology. 1987; 27: 121-26.
[23]
Youngstrom EA, Bartkowski DP. Vulvar embryonal rhabdomyosarcoma: A case report. Journal of Pediatric Urology. 2013; 9 (4): e144-46.
[24]
Park HJ, Jeon YK, Lee AH, Oh YH, Park SH, Jung KC. Use of the JL1epitope, which encompasses the non glycosylation site of CD43, as a marker of immature/neoplasticLangerhans cells. Am J Surg Pathol. 2012; 36: 1150-57.
[25]
Cohen BA, Hood A. Xanthogranuloma: Report on clinical and histologic findings in 64 patients. Pediatr Dermatol. 1989; 6: 262-6.
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